AO_ Chemische Synthese

Chemical Synthesis

Oxidizing agents 

Most organic chemists know m-chloro-peroxybenzoic acid as a versatile oxidant for selective oxidations from the laboratory. However, this reagent is expensive and too difficult to handle to be used on an industrial scale. An alternative oxidizing agent with similar reactivity that is suitable for industrial purposes is peracetic acid. For various numbers of oxidations also hydrogen peroxide can be used.


Hydrogen peroxide is an economical but powerful and environmentally benign oxidizing agent that has found many uses in the chemical industry for the manufacture of organic compounds. Due to its low molecular weight, hydrogen peroxide is a more efficient oxidizing agent on a weight per weight basis than potassium dichromate or permanganate. It is a stable and safe chemical when handled correctly and offers the advantage of being soluble in water, in many organic solvents, or in the substrate itself. Last but not least, hydrogen peroxide has an environmentally benign profile since it decomposes to just water and oxygen.

The various applications where hydrogen peroxide is used as the oxidizing agent of choice include the following examples in chemical synthesis:

  • Propylene oxide (alkene epoxidation via HPPO process)

  • Organic peroxide initiators (e.g. benzoyl peroxide, lauryl peroxide) 

  • Epoxidized soy bean oil plasticizers (fatty acid epoxidation) 

  • Flame retardants (bromination) 

  • Initiator for catalytic polymerization reactions (free radical source) 

  • Catechol production (hydroxylation) 

  • Preparation of pharmaceutical precursors (oxidation) 

  • Amine oxide surfactants (N-oxidation) 

  • Herbicide production (S-, N-oxidation) 

  • Percarboxylic acid production (e.g. peracetic acid)

Depending on the initial quality requirements for chemical synthesis applications, Evonik offers its HYPROX® standard hydrogen peroxide grade as well as its PERSYNT® high purity hydrogen peroxide grade.

 

Evonik offers PERACLEAN® 35 and PERACLEAN® 40, high strength equilibrium peracetic acid, which are the products of choice for chemical synthesis.
High strength PERACLEAN® grades offer unique properties as an oxidant:

  • High oxidative power

  • Selective reactions by nonradical pathways

  • Safe and convenient liquid handling

  • No transition metals involved

  • No halogenated by-products

  • Effluents are readily biodegradable

  • Available ready to use in large quantities at a competitive price

PERACLEAN® 35 and PERACLEAN® 40 can be used for a wide range of oxidation reactions such as:

  • Epoxidation of olefins

  • Oxidation of thioethers to sulfoxides or sulfones

  • Oxidation of tert. amines to amine oxides

  • Oxidation of pyridines to pyridine oxides

  • Baeyer-Villiger oxidation of acylbenzenes to o-acylphenols

 

Learn more in our free eBook

Guide to hydrogen peroxide and peracetic acid

The Modern Chemist’s Guide to Hydrogen Peroxide and Peracetic Acid

Please check with your regional contact about the right grades and formulations for your application.

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